As indicated in the `OTB installation <https://www.orfeo-toolbox.org/CookBook/Installation.html#linux-x86-64>`_, do not forget to initialize the environment when you launch a new terminal:
As indicated in the `OTB installation
<https://www.orfeo-toolbox.org/CookBook/Installation.html#linux-x86-64>`_, you need to modify some files to have functional OTB installation. To use Python3 you need in the file otbenv.profile modify ``lib/python`` into ``lib/python3``, for variable PYTHONPATH
Then you can install Python Numpy for OTB bindings